Profile
Dr Guoying CHEN
Research Fellow
Dr Chen obtained his PhD from the National University of Singapore in 2012, majoring in organic chemistry. After graduation, he joined Experimental Therapeutic Centre, ASTAR as a medicinal chemist, doing fragment-based drug discovery. He then worked as a process chemist for drug manufacturing. Before joining CARES, he was a consultant at BIPO Singapore. Dr Chen's role at CARES was to develop novel processes for drugs using digital workflow. He has transferred the process from batch to flow, the flow process is practical and can be applied on a pilot and manufacture scale.
Dr Chen's next step will be to join FMC Singapore as a chemist in 2023.
Past Members
Past Members
Research Interest
- Using machine learning to study the synthetic process for small molecule drug
- Process chemistry in the application of pharmaceutical industry
- High throughput experiment platform application
Key Publications
Chen, G.-Y., Ng, F.M., Tan, Y.W., Poulsen, A., Seetoh, W., Lin, G., Kang, C., Then, S.W., Ahmad, N.H., Wong, Y.L., Ng, H.Q., Chia, C.S.B., Lau, Q.Y., Hill, J., Hung, A.W. and Keller, T.H. (2015), Application of Fragment-Based Drug Discovery against DNA Gyrase B. ChemPlusChem, 80: 1250-1254. https://doi.org/10.1002/cplu.201500197
Guo-Ying Chen, Fangrui Zhong, and Yixin Lu. 2012. Asymmetric Allylic Alkylation of Isatin-Derived Morita–Baylis–Hillman Carbonates with Nitroalkanes, Organic Letters, 14(15), 3955-3957, DOI: 10.1021/ol301962e
Wei Zeng, Guo-Ying Chen, Yong-Gui Zhou, and Yu-Xue Li. 2007. Hydrogen-Bonding Directed Reversal of Enantioselectivity, Journal of the American Chemical Society, 129(4), 750-751, DOI: 10.1021/ja067346f