Profile
Asst Prof Marie LOH
Principal Investigator
Asst Prof Marie Loh is an Assistant Professor at the Lee Kong Chian School of Medicine at Nanyang Technological University, Singapore, Senior Research Scientist at the Genome Institute of Singapore, Honorary Senior Lecturer at Imperial College London and a Co-Investigator of the SG100K study.
Dr Loh is a molecular epidemiologist with a long-standing interest in the role of genetics and epigenetics underlying complex diseases, with a specific focus on ethnic differences in risk and outcome. Her current research focuses on combining population health with molecular phenotyping approaches to advance knowledge and understanding of non-communicable diseases.
She has published more than 100 papers to date, including high-impact journals such as Lancet Diabetes and Endocrinology, Nature Genetics, and Nature. She has played a pivotal role in multiple international collaborative studies including the EU FP7 EpiMigrant, Translating Omics into A Stratified approach for prevention of T2D (TOAST) and South Asian(SAS)-T2D studies where we identified novel epigenetic and genetic loci associated with incident Type 2 Diabetes (T2D), and the Asian Skin Microbiome Programme 2 (ASMP2) study which investigates the functional roles of skin microbiome components and uncover novel bi-directional interactions between the host and skin microbiome, with environmental factors.
Singapore - NTU
Researchers
HD4
Research Interest
Key Publications
ResearchGate profile
Loh M, Zhang W, Ng HK, …, Kooner JS, Saleheen D, Chambers JC. Identification of genetic effects underlying Type 2 Diabetes in South Asian and European populations. Commun Biol 5, 329 (2022). IF: 6.27
Hawe JS, Wilson R, Schmid K, …, Loh M, Heinig M, Gieger C, Waldenberger M, Chambers JC. Genetic variation influencing DNA methylation provides new insights into the molecular pathways regulating genomic function. Nature Genetics, 54(1):18-29 2022 Jan. IF: 38.33
3. Chen Y, Kassam I, Lau SH, Kooner JS, Wilson R, Peters A, Winkelmann J, Chambers JC, Chow VT, Khor CC, van Dam RM, Teo YY, Loh M*, Sim X*. Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals. Clin Epigenetics. 2021 Oct 20;13(1):195. IF: 6.55
4. Kassam I, Tan S, Gan FF, …, Loh M.. Genome-wide identification of cis DNA methylation quantitative trait loci in three Southeast Asian populations. Human Molecular Genetics 2021 Feb 6:ddab038. IF: 4.48
5. Loh M, Zhou L, Ng HK and Chambers JC. Epigenetic disturbances in obesity and diabetes: epidemiological and functional insights. Molecular Metabolism 2019 Sep; 27S:S33-S41. IF: 6.29